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Technical University of Munich
Molecular Food Technology and Safety
Quantification of lipid droplet and adipocyte size and number in microscopy images
«
Thanks to Wimasis we are now able to extract more information from every image we take
»
Dr. Tobias Fromme
Research scientist, Chair for Molecular Nutritional Medicine Technische Universität München
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Inhibition of vessel growth (angiogenesis) in tumors
The Ludwig-Maximilians-University (LMU) Munich
Center for Drug Research, Chair of Pharmaceutical Biology (Prof. Angelika Vollmar)
The Center for Drug Research covers all research areas around the development of novel drug – from chemical synthesis to innovative formulations. At the Chair of Pharmaceutical Biology (Prof. Dr. Angelika Vollmar) we investigate the pharmaceutical potential of natural compounds, be it of plant, animal or microbial origin.

Our main focus lies on tumor biology, with tumor angiogenesis (Prof. Dr. Stefan Zahler) as a central topic. Inhibiting the vessel growth in tumors in order to “starve” the malignancy is an old therapeutic concept, which has led to some clinical success, but still has its limits: due to evasive strategies of the tumors and to development of resistances we are still in need of novel therapeutic targets and inhibitors of angiogenesis.
Therefore, not only try to get a better academic understanding of the angiogenesis process, but also screen novel inhibitors. More complex angiogenesis assays, like the tube formation assay, are image based and tedious to evaluate by hand.

Therefore they often are of limited use for screening purposes. The WimTube module overcomes this problem: it enables a robust rational evaluation of tube formation assays, and allows us to use this assay in a medium throughput screening approach.
In addition to the highly reproducible analysis, we also get valuable morphological information, which has to date not been used in classical evaluation routines.
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Importance of the communication between different types of imune cells
The Ludwig-Maximilians-University (LMU) Munich
The division of clinical pharmacology (Prof. Dr. Stefan Endres, work group of Dr. David Anz)
For the homeostasis of the immune system communication between the different types of immune cells is of major importance. Communication takes place via soluble factors like cytokines and via direct cell-cell-interaction.

For example during the generation of an immune response, where antigen presenting cells that have processed an antigen and got maturated by pathogen-associated-molecular-patterns secret different types of cytokines in order to activate surrounding immune cells and attract t-helper-cells. Only if these t-helper-cells express the right t-cell-receptor for the specific antigen, an immune response can be evoked. This process is important in the context of defense against invading pathogens, but also for example in the context of immunological recognition and eventually rejection of tumor cells.

In cooperation with Wimasis we were able to develop a new method which can be used to automatically analyze migration and interaction of cells.
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  • Importance of the communication between different types of imune cells
    View case study
  • Inhibition of vessel growth (angiogenesis) in tumors
    View case study
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