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Autophagy represents the major process for degradation of aggregated cellular proteins and dysfunctional organelles, so alterations in autophagy are involved in pathogenesis of many diseases, like nervous system disorders. WimAutophagy is our Image Analysis Solution specifically designed to monitorize the autophagy process, by detecting the autophagosomes in the cytoplasm from cell or tissue cultures images.

Thanks to our high-end image processing algorithms, WimAutophagy detects cell nuclei and allocates the autophagosomes to the corresponding nuclei, so useful data per cell can be obtained from our analysis. It is also optimized to distinguish between isolated and clustered autophagosomes, in order to be able to estimate the number of autophagosomes and puncta per cell. WimAutophagy is able to work with many different types of image acquisition such as epifluorescence and confocal microscopy in adherent cell lines.

Besides, the flexibility of WimAutophagy tool makes it suitable for other image kinds; so, if your autophagy images do not fulfill the requirements above, don’t hesitate to contact us and get a trial for your images.

Autophagy assay images granted by the The Biological Research Centre (CIB), of the Spanish National Research Council (CSIC).
  • Lucía García Ledo . Role of autophagy in neurodegeneration and new for its study PhD Thesis - Complutense University of Madrid. September 2015
  • Natalia Rodríguez-Muela, Hiroshi Koga, Lucía García-Ledo, Pedro de la Villa, Enrique J. de la Rosa, Ana María Cuervo, Patricia Boya. Balance between autophagic pathways preserves retinal homeostasis Aging Cell. June 2013
  • Marques, Rita Francisco. Monóxido de carbono como agente protector num modelo de hipóxia-isquémia e reperfusão através da activação da autofagia PhD Thesis - Universidade Nova de Lisboa. October 2012
  • View all
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Please, choose the quantity
  • 100 images 350.00 €
  • 250 images 750.00 €
  • 500 images 1,000.00 €
  • 1000 images 1,500.00 €
  • 2000 images 2,500.00 €
  • 5000 images 6,000.00 €
  • 10000 images 10,000.00 €
  • 20000 images 18,000.00 €
(Tax free)
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Analysis data contain
  • ✔ Number of cells
  • ✔ Estimated autophagosome area and mean intensity
  • ✔ Mean number of puncta and autophagosomes per cell
  • ✔ Mean Nucleus area
  • ✔ Area of nucles, citoplasm and autophagosomes
  • ✔ Number of autophagosomes, by quantifying isolated and estimating clusters population
Would you like to get any other parameter? Ask for it!
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Case studies
Centro de Investigaciones Biológicas (CIB-CSIC)
Autophagy in Development and Disease
Our lab uses cellular and animal models to understand the physiological roles of autophagy and its implications during disease.

Autophagy is an essential intracelullar degradation pathway that recycles cell components generating new building blocks and energy to maintain cellular homeostasis. Autophagy plays an important role in the response to nutrient starvation; the recycling of damaged organelles and is a survival mechanism under stress conditions. In addition, autophagy could as well participate in programmed cell death.

We are interested in the implication of autophagy during development and in the relationship of autophagy with basic processes such as proliferation, differentiation and cell death. Moreover we want to understand how autophagy deregulation may play a role in several pathological situations such as cancer and neurodegenerative conditions.

We have several projects with pharmaceutical companies to screen for new drugs that modulate autophagy with the aim to find new treatments for cancer, neurodegenerative diseases and other pathological conditions.

Wimasis has allowed us to speed up and standardize the process of autophagosome quantification in cells and tissues.
View case study
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