Department of Biology, Faculty of Science and Letters
WimCAM allows us to analyze vascularization reliably in CAM assay as an alternative angiogenesis model system.
Dr. Gamze Tan
Research scientist, Department of Biology, Aksaray University
Our main scientific interest is to combine biology and nanotechnology, meeting in cancer
studies using multifunctional nanoparticles. Wimasis enables us to measure both in vitro
scratch assay and in-ovo CAM assay by giving results in a shorter time and more standardized
manner. Initial and final scratch sizes are determined using the WimScratch analysis tool and
the difference between the two is used to determine migration distance using ratio of scratch
area to cell covered area.
We also frequently use CAM model in angiogenesis studies. Instead of using the macroscopic
scoring method, thanks to WimCAM we can reliably measure many parameters such as vesseldensity, total vessel network length, total branching points, total nets, and segment properties,
hidden details in the images obtained after the nanomaterials-biological system interaction in
CAM assay, thus we can make comparisons between these measurements in a short time. It
also allows seeing measurements on the processed image after all these analyzes and makes
you evaluate measurement quality. By this way, we cannot only save time but also get more
reliable morphological information than classical methods.
As it is known, this is crucial for a better understanding of the relationship between
cells/tissues and nano-sized structures and for making way for successful clinical applications.
Thanks to Wimasis’ online tools, it is now possible to make more informative analyzes about
interactions between nanomaterials and biological systems.
The Ludwig-Maximilians-University (LMU) Munich
With the help of Wimasis we can really do quantitative analysis of image-based angiogenesis assays
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