The division of clinical pharmacology (Prof. Dr. Stefan Endres, work group of Dr. David Anz)
Thanks to Wimasis we were able to realize a totally new method and save a lot of time
AG Dr. Anz Klinische Pharmakologie LMU München
For the homeostasis of the immune system communication between the different types of immune cells is of major importance. Communication takes place via soluble factors like cytokines and via direct cell-cell-interaction.
For example during the generation of an immune response, where antigen presenting cells that have processed an antigen and got maturated by pathogen-associated-molecular-patterns secret different types of cytokines in order to activate surrounding immune cells and attract t-helper-cells. Only if these t-helper-cells express the right t-cell-receptor for the specific antigen, an immune response can be evoked. This process is important in the context of defense against invading pathogens, but also for example in the context of immunological recognition and eventually rejection of tumor cells.
In cooperation with Wimasis we were able to develop a new method which can be used to automatically analyze migration and interaction of cells.
WimCAM allows us to analyze vascularization reliably in CAM assay as an alternative angiogenesis model system.